Automated synthesis and purification of [18F]fluoro‐[di‐deutero]methyl tosylate |
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Authors: | Friederike Beyerlein Markus Piel Sabine Höhnemann Frank Rösch |
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Affiliation: | Institute of Nuclear Chemistry, Johannes Gutenberg‐University, , 55128 Mainz, Germany |
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Abstract: | Automated synthetic procedures of [18F]fluoro‐[di‐deutero]methyl tosylate on a GE TRACERlab FX F‐N module and a non‐commercial synthesis module have been developed. The syntheses included azeotropic drying of the [18F]fluoride, nucleophilic 18F‐fluorination of bis(tosyloxy)‐[di‐deutero]methane, HPLC purification and subsequent formulation of the synthesized [18F]fluoro‐[di‐deutero]methyl tosylate (d2‐[18F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (>98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated 18F‐fluoromethylated imaging probes in the future. Copyright © 2013 John Wiley & Sons, Ltd. |
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Keywords: | automated synthesis 18F‐fluoromethylation [18F]fluoromethyl tosylate [18F]fluorine PET |
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