|
|||||
|
|
Detection of paranasal ectopic adrenocorticotropic hormone‐secreting pituitary adenoma by Ga‐68‐DOTANOC positron‐emission tomography–computed tomography |
|
| Authors: | Johannes A Veit MD Bernhard Boehm MD PhD Markus Luster MD PhD Angelika Scheuerle MD Nicole Rotter MD PhD Gerhard Rettinger MD PhD Marc Scheithauer MD PhD |
| Institution: | 1. Department of ENT Surgery, University Hospital Ulm, , Ulm, Germany;2. 1st Department of Internal Medicine, Endocrinology, University Hospital Ulm, , Ulm, Germany;3. Department of Nuclear Medicine, University Hospital Ulm, , Ulm, Germany;4. Department of Neuropathology, University Hospital Ulm/BKH Günzburg, , Günzburg, Germany |
| Abstract: | Ectopic adrenocorticotropic hormone (ACTH)‐secreting tumors account for approximately 10% of Cushing's syndrome (CS). We present an extremely rare case of a patient with CS caused by an ectopic ACTH‐secreting pituitary adenoma (EAPA) of the ethmoid sinus. The tumor was identified by positron‐emission tomography–computed tomography (PET/CT) using the somatostatin receptor analogue Ga‐68‐DOTANOC. Transnasal endoscopic resection was performed and the patient showed significant clinical improvement with normalization of the endocrine pituitary axis. Immunostaining showed a somatostatin receptor 2 and 5‐positive ACTH‐producing adenoma. In patients with ectopic ACTH secretion, Ga‐68‐DOTANOC‐PET/CT may play an important role in the localization of EAPA. Transnasal endoscopic resection is the therapy of choice. |
| Keywords: | Cushing's syndrome ectopic Cushing Ga‐68‐DOTANOC positron‐emission tomography– computed tomography ectopic pituitary adenoma ectopic adrenocorticotropic hormone production |