Effect of sodium pyridinethione on the uptake and distribution of nickel in rats,ferrets and guinea-pigs |
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Authors: | Kathleen Borg-Neczak Hans Tjälve |
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Institution: | (1) Swedish University of Agricultural Sciences, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Biomedicum, Box 573, S-751 23 Uppsala, Sweden , SE |
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Abstract: | Oral administration of sodium pyridinethione together with Ni2+ (using 63Ni2+ as a tracer) to rats, ferrets and guinea-pigs produced highly increased tissue levels of the metal in several tissues in
comparison with animals given the Ni2+ alone. Ni2+ forms a lipophilic complex with pyridinethione and it can be assumed that a facilitated passage of the Ni2+ across the cellular membranes of various tissues is important for the observed effects. Pigmented tissues (e. g. the eye
melanin), the pancreatic islets, the nervous system and striated muscles showed high levels of Ni2+ in animals given sodium pyridinethione. However, in some instances marked species differences were observed. Thus, microautoradiography
indicated an uptake of Ni2+ both in the β- and α-cells in the pancreatic islets in the rat, whereas in the guinea-pig only some cells (probably the α-cells)
accumulated high levels of Ni2+. In the ferret sodium pyridinethione induced a high uptake of Ni2+ in the heart muscle, which was not seen in the other species. The Ni2+ is probably taken up in the various tissues complexed to pyridinethione. Within the tissues the complex may dissociate and
the Ni2+ may bind to some endogeneous tissue components. The affinity of the Ni2+ for the endogeneous ligands in relation to the affinity for the pyridinethione may be of importance for the effects on the
disposition of the Ni2+. The species variations may be related to differences in the structural conformations of the endogeneous Ni2+-binding ligands.
Received: 25 October 1993/Accepted: 25 January 1994 |
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Keywords: | : Sodium pyridinethione – Nickel – Rat – Ferret – Guinea-pig |
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