羟基喜树碱联合化疗治疗晚期胃癌近期疗效观察

目的观察羟基喜树碱(HCPT)联合化疗治疗晚期胃癌的近期疗效和毒性.方法 91例晚期胃癌病人随机分为治疗组和对照组.治疗组46例,接受HCPT 10 mg第1～5天,CF 100 mg第1～5天,5-Fu 500 mg/m2 第1～5天,DDP 30 mg/m2第1～3天;对照组45例接受CF 100 mg第1～5天,5-Fu 500 mg/m2第1～5天,DDP 30 mg/m2第1～3天.以上两个方案21 d为一周期,2周期后评价疗效.结果两组有效率分别为60.9%(28/46),40.0%(18/45),差异有显著性(P＜0.05).两组不良反应差异无显著性(P＞0.05).结论 HCPT联合化疗治疗晚期胃癌有效率高,毒性无明显增加,值得继续研究.

Efficacy of hydroxycamptothecin-based combination chemotherapy in advanced gastric cancer

Objective To observe the efficacy and toxicity of hydroxycamptothecin(HCPT)-based combination chemotherapy in advanced gastric cancer.Methods Ninety one patients with gastric cancer were randomly devided into treatment group and control group.The treatment group(n=46) received HCPT 10 mg d 1-5,CF 100 mg d 1-5,5-Fu 500 mg/m~2 d 15,and DDP 30 mg/m~2 d 1-3,q3w for 2 cycles.The control group(n=45) received CF 100 mg d 1-5,5-Fu 500 mg/m~2 d 1-5 and DDP 30 mg/m~2 d 13,q3w for 2 cycles.Results The response rates of the two groups are 60.9%(28/46) and 40.1%(18/45) respectively.There is significant difference between the two groups(P<0.05).The side-effects of two groups have no significant difference(P>0.05)?Conclusion HCPT-based combination chemotherapy is effective and safe for advanced gastric cancer and worthwhile of further study.