| 表皮生长因子影响肿瘤患者舌苔变化的分子机制研究 |
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| 引用本文： | 许冬青,王明艳,狄洌,詹瑧. 表皮生长因子影响肿瘤患者舌苔变化的分子机制研究[J]. 细胞与分子免疫学杂志, 2002, 18(6): 598-600 |
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| 作者姓名： | 许冬青 王明艳 狄洌 詹瑧 |
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| 作者单位： | 1. 南京中医药大学基础医学院微生物学与免疫学教研室,江苏,南京210029
2. 南京农业大学理学院 |
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| 基金项目： | 国家自然科学基金资助No .3 0 0 70 910 |
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| 摘 要： | 目的 研究表皮生长因子（EGF）对食管癌细胞Eca-109细胞周期及表皮生长因子受体（EGF－R）表达的影响，探讨EGF促进肿瘤患者舌苔增厚的分子机制。方法 应用流式细胞术，检测EGF－R的表达和细胞周期。结果 EGF能明显促进Eca-109细胞膜上EGF－R的表达，使细胞增殖活性大大增强。结论EGF有是通过促进EGF－R的表达影响舌苔形成。
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| 关 键 词： | 分子机制 表皮生长因子 细胞周期 流式细胞术 舌苔 食管癌 |
| 文章编号： | 1007-8738(2002)06-598-03 |
| 修稿时间： | 2002-04-09 |
Molecular mechanism of the effects EGF on tongue fur of tumor patients |
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| XU Dong qing ,WANG Ming yan ,DI Lie ,ZHAN Zhen Basic Medical College of Nanjing University of Traditional Chinese Medicine,Nanjing , Science College of Nanjing Agricultural University,Jiangsu province,China. Molecular mechanism of the effects EGF on tongue fur of tumor patients[J]. Chinese journal of cellular and molecular immunology, 2002, 18(6): 598-600 |
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| Authors: | XU Dong qing WANG Ming yan DI Lie ZHAN Zhen Basic Medical College of Nanjing University of Traditional Chinese Medicine Nanjing Science College of Nanjing Agricultural University Jiangsu province China |
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| Affiliation: | XU Dong qing 1,WANG Ming yan 1,DI Lie 2,ZHAN Zhen 1 1 Basic Medical College of Nanjing University of Traditional Chinese Medicine,Nanjing 210029, 2Science College of Nanjing Agricultural University,Jiangsu province,China |
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| Abstract: | Aim To investigate the effects of epidermal growth factor (EGF) on cell cycle and EGF R expression of esophagus carcinoma cell line Eca 109 and explore molecular mechanism of influencing tongue fur of the tumor patients by EGF. MethodThe expression of EGF R and cell cycle of Eca 109 cells were detected by flow cytometry(FCM). Results EGF could significantly up regulate increase the expression of EGF R and enhance the proliferation of Eca 109 cells. Conclusion Increased expression of EGF R may be a main cause of enhancemant of tongue fur formation by EGF. |
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| Keywords: | EGF EGF R cell cycle FCM fur of tongue |
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