PROX-1与Ki-67在胆管癌中的表达及意义

目的：探讨PROX-1及Ki-67在胆管癌中表达及意义。 方法：用免疫组化法检测46例肝门部胆管癌患者（伴淋巴结转移29例，无淋巴结转移17例）癌组织与23例胆管良性病变患者胆管组织中PROX-1及Ki-67的表达，分析PROX-1及Ki-67的表达与胆管癌淋巴转移及其他临床病理因素的关系。 结果：PROX-1与Ki-67两者的阳性表达率在良性病变胆管组织、无淋巴结转移胆管癌组织、伴淋巴结转移胆管组织中依次增高，差异均有统计学意义（均P<0.05）；两者的阳性表达率均与胆管癌的分化程度有关（均P<0.05），而与患者的性别、年龄无关（P>0.05）；胆管癌组织中PROX-1与Ki-67表达正相关（r=0.831，P<0.05）。 结论：PROX-1与Ki-67的高表达与胆管癌的恶性生物学行为密切相关，且两者表达量之间存在关联性。

PROX-1 and Ki-67 expressions in cholangiocarcinoma tissues and their significance

Objective: To investigate the PROX-1 and Ki-67 expressions in cholangiocarcinoma tissues and their significance. Methods: The PROX-1 and Ki-67 expressions in cancer tissues form 46 patients with hilar cholangiocarcinoma (29 cases with lymph node metastases, and 17 cases without lymph node metastasis) and bile duct tissues from 23 cases with benign biliary disease were determined by immunohistochemical staining. The relations of PROX-1 and Ki-67 expressions with lymph node metastasis and other clinicopathologic factors of cholangiocarcinoma were analyzed. Results: Positive expression rates of PROX-1 and Ki-67 were both increased in an ascending order in bile duct tissue of benign biliary disease, cholangiocarcinoma tissue without lymph node metastasis and cholangiocarcinoma tissue with lymph node metastases, and all differences had statistical significance (all P<0.05). The positive expression rates of PROX-1 and Ki-67 were both associated with the degree of differentiation of the tumor (both P<0.05), and were not related with sex and age of the patients (all P>0.05). There was a positive correlation between PROX-1 and Ki-67 expression in cholangiocarcinoma tissue (r=0.831, P<0.05). Conclusion: PROX-1 and Ki-67 over-expressions are closely related to the malignant biological behavior of cholangiocarcinoma, and furthermore, there is relevance between their expression levels.