基底细胞样乳腺癌中HIF-1α及Glut-1的表达及意义

目的:探讨缺氧诱导因子1α(HIF-1α)及葡萄糖转运蛋白1(Glut-1)蛋白在基底细胞样乳腺癌(BLBC)中的表达及临床意义。方法:采用免疫组化方法检测95例BLBC及其癌旁乳腺组织与708例非BLBC组织中HIF-1α及Glut-1蛋白的表达,分析两者表达与BLBC临床病理因素的关系。结果:HIF-1α及Glut-1蛋白在BLBC组织的阳性表达率均明显高于癌旁组织与非BLBC组织(均P0.05),两种蛋白的表达呈明显正相关(r=0.368,P0.05)。结论:HIF-1α和Glut-1的表达在BLBC组织中同时升高,两者可能共同参与了BLBC的发生、发展,并可能作为评估BLBC患者预后的指标。

Expression and significance of HIF-1α and Glut-1 in basal-like breast carcinoma

Objective: To investigate the expression and clinical significance of hypoxia inducible factors 1α (HIF-1α) and glucose transporter 1 (Glut-1) in basal-like breast carcinoma (BLBC). Methods: The protein expressions of HIF-1α and Glut-1 in 95 specimens of BLBC and their adjacent breast tissue, and 708 samples of non-BLBC tissue were detected by immunohistochemical staining, and their relations with the clinicopathologic factors of BLBC were analyzed. Results: The positive expression rate of either HIF-1α or Glut-1 protein in BLBC tissue was significantly higher than that in adjacent breast tissue and non-BLBC tissue (all P<0.05), and both HIF-1α and Glut-1 protein expressions were associated with lymph node metastasis and clinical stage of BLBC (all P<0.05); there was a significantly positive correlation between HIF-1α and Glut-1 expression in BLBC tissue (r=0.368, P<0.05). Conclusion: HIF-1α and Glut-1 synchronously overexpress in BLBC tissue, which may co-participate in the occurrence and development of BLBC, and can be potentially used as a prognostic index for BLBC patients.