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Micrencephaly in Rats Caused by Maternal Hyperthermia on Days 13 and 14 of Pregnancy1
Authors:Antony J. HARDING  Marshall J. EDWARDS
Abstract:ABSTRACT: Hyperthermia was induced in rats twice at an interval of eight hours on both days 13 and 14 of gestation by partial immersion in a water-bath. Deep rectal temperature was raised to 42.5°C for five minutes. Body weights of newborn rats were reduced, but by three weeks of age compensatory post-natal growth had eliminated the defect. In both newborn and 21-day-old rats, brain weight was significantly reduced compared with controls of similar body weight. No other anomalies were found.
Keywords:birth defects  hyperthermia teratogenesis  micrencephaly  rats
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