高尔基磷酸化蛋白3在结直肠癌中的表达与预后的关系

目的：探讨结直肠癌组织中高尔基磷酸化蛋白3（GOLPH3）的表达以及与结直肠癌预后的关系。方法：用免疫组化方法检测123例结直肠癌组织中GOLPH3、c-Myc、P27的表达，分析GOLPH3表达与患者临床病理特征的关系、与c-Myc和P27的关系及与患者预后的关系。结果：GOLPH3在结直肠癌组织中的阳性表达率为60.2%（74/123）；GOLPH3的阳性表达率与肿瘤浸润深度、TNM分期、淋巴结转移和远处转移，以及c-Myc表达有关（均P<0.05），但与性别、年龄、肿瘤大小、肿瘤分化、CEA水平、P27表达无关（P>0.05）；结直肠癌组织组中GOLPH3表达与c-Myc表达呈正相关（r=0.263，P<0.05）。全组患者5年总生存率为56.9%，GOLPH3阳性表达者为48.6%，GOLPH3阴性表达者为69.4%；单因素生存分析表明，GOLPH3阳性表达的结直肠癌患者生存时间明显低于GOLPH3阴性表达者（P<0.05）。结论：结直肠癌中GOLPH3的表达可能与c-Myc有协同作用，其阳性表达患者预后较差。

Relationship between golgi phosphorylation protein 3 expression and prognosis in colorectal cancer

Objective: To investigate the golgi phosphoprotein 3 (GOLPH3) expression in colorectal cancer tissues and its relation with prognosis of colorectal cancer.Methods: The GOLPH3 along with the c-Myc and P27 expressions in 123 specimens of colorectal cancer were determined by immunohistochemical staining, and the relations of GOLPH3 expression with the clinicopathologic features, the c-Myc and P27 expressions and the prognosis of the patients were analyzed.Results: The positive expression rate of GOLPH3 in these colorectal cancer tissues was 60.2% (74/123). The positive GOLPH3 expression was significantly related to tumor invasion depth, TMN stage, lymph metastasis and distant metastasis as well as c-Myc expression (all P<0.05), but irrelevant to sex, age, tumor size, differentiation, CEA level and P27 expression (all P>0.05). The GOLPH3 expression was positively correlated with c-Myc expression in colorectal tissue (r=0.263, P<0.05). The 5-year overall survival rate was 56.9% for the entire group of patients, was 48.6% for patients with positive GOLPH3 expression and 69.4% for those with negative GOLPH3 expression. Univariate survival analysis showed that the survival rate in patients with positive GOLPH3 expression was significantly lower than that in patients with negative GOLPH3 expression (P<0.05).Conclusion: GOLPH3 expression may have a synergistic action with c-Myc in colorectal cancer and those with positive GOLPH3 expression may face an unfavorable prognosis.