| ciRS-7/miR-7轴调控肿瘤生长转移的研究进展 |
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| 引用本文： | 刘彦,周超 综述 杨永学 审校.ciRS-7/miR-7轴调控肿瘤生长转移的研究进展[J].中国普通外科杂志,2015,24(7):1027-1031. |
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| 作者姓名： | 刘彦 周超 综述 杨永学 审校 |
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| 作者单位： | （1. 四川省成都市第五人民医院 消化内科，四川 成都 611130；2. 四川省成都市第六人民医院 普通外科，四川 成都 610051） |
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| 摘 要： | 抑癌因子miRNA-7（miR-7）在肿瘤组织发生中表达下降，但机制未明。最近发现环状RNA-7（ciRS-7）具有miR-7海绵样吸附作用，从而抑制miR-7的功能，该发现为探索miR-7在肿瘤中表达降低的原因开辟了新的途径。目前认为ciRS-7/miR-7轴不仅具有重要的生物学作用，同时参与机体多种疾病的发生发展。笔者就ciRS-7/miR-7轴调控肿瘤生长转移的研究进展进行综述。
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| 关 键 词： | 肿瘤 微RNAs 环状RNAs 综述文献 |
| 收稿时间： | 2015/5/9 0:00:00 |
| 修稿时间： | 2015/6/16 0:00:00 |
Regulative role of ciRS-7/miR-7 axis in tumor growth and metastasis: recent advances |
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| LIU Yan,ZHOU Chao,Yang Yongxue.Regulative role of ciRS-7/miR-7 axis in tumor growth and metastasis: recent advances[J].Chinese Journal of General Surgery,2015,24(7):1027-1031. |
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| Authors: | LIU Yan ZHOU Chao Yang Yongxue |
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| Abstract: | Tumor suppressor miRNA-7 (miR-7) is found down-regulated in cancer tissues, but the underlying mechanism remains elusive. Recent studies demonstrated that circular RNA-7 (ciRS-7) acts as a sponge for miR-7 and thus can inhibit the miRNA-7 activity. This finding provided a new perspective for revealing the mechanisms of decreased expression of miR-7 in tumors. It is now believed that the ciRS-7/miR-7 axis not only has important biological functions, but participates in the occurrence and development of a range of diseases. Here, the authors present the research progress in ciRS-7/miR-7 axis regulating tumor growth and metastasis. |
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| Keywords: | Neoplasms MicroRNAs Circular RNAs Review |
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