胰腺导管内乳头状黏液肿瘤的分子病理学研究进展

胰腺导管内乳头状黏液肿瘤(IPMN)是一种较少见的胰腺囊性肿瘤,具有恶变为胰腺导管腺癌的风险,且一旦发生恶变,预后较差。目前国内外针对IPMN的研究较少,因此,更好地理解其发生发展的分子病理学机制对于该疾病的诊断、治疗和预后改善具有重要意义。已发现多种癌基因、抑癌基因、信号通路等分子参与了IPMN的发生发展及恶变过程,笔者着重对IPMN的分子病理学研究进展进行综述。

Progress on molecular pathology of intraductal papillary mucinous neoplasms

Intraductal papillary mucinous neoplasms (IPMNs) are a rare type of pancreatic cystic tumor, with risk of transforming to pancreatic ductal adenocarcinoma and once it occurs may confer a poor prognosis. Currently, studies on IPMNs are still scarce at home and abroad. Therefore, better understanding the molecular pathological mechanism responsible for IPMNs may have great importance in diagnosis and treatment as well as improving the prognosis of IPMNs. A great amount of oncogenes, tumor suppressor and signaling molecules have been found involving the process of occurrence and development of IPMNs as well as the malignant transformation. In this paper, the authors mainly address the research progress on molecular pathology of IPMNs.