克山病血清流行病学调查研究——克山病病毒病因实验研究之二

为了确定作者等1975年从四川西昌克山病流行区一个亚急克山病儿分离出来的川便5病毒与克山病的关系,我们于1990年4～6月进行了克山病血清流行病学调查。调查对象为吉林省长白朝鲜族自治县既往克山病人54例(包括慢性克山病和潜在性克山病各2例),非克山病人54例和非病区长春市非克山病人42例。所用方法为微量中和试验法。调查结果:(1)在川便5病毒与克山病之间存在特异的、此病毒抗原与长白县既往克山病人血内抗体相符合的关系,因此我们认为川便5病毒可能是克山病致病因素之一。(2)川便5与标准Echo_6病毒虽属同一个血清型,但它们的抗原性和致病性是不同的,无论在前者或后者方面,川便5病毒均显著高于标准Echo_6病毒;所以川便5病毒可能是Echo_6病毒的一个新亚型,即Echo_(6-3)。

THE SEROEPIDEMIOLOGIC STUDY ON KESHAN DISEASE

For determining the relation between Chuan Stool (CS5) virus and Keshan disease, in April-June 1990, a seroepidemiologic study of Keshan disease was carried out by means of microneutralization test. The antigen we used was the CS5 virus isolated from a subacute Keshan disease patient in july 1975. The subjects of this study include 50 acute Keshan disease patie- nts, 2 of chronic Keshan disease, 2 of latent Keshan disease, and 54 persons never affected by Keshan disease as control, who lived in epidemic district of Keshan disease, also in Changbai County of Jilin province, and other 42 controls, lived in Changchun City where there was no Keshan disease. The results of this study may be briefly stated as follows 1. Between CS5 virus and Keshan disease exists a specific pathogenic relation, that the antigen of CS5 virus fits in with the antibody contained in the body of these tested Keshan disease patients. Therefore we consider that CS5 virus is one of the pathogenic factors for Keshan disease. 2. Although CS5 virus and standard Echo6 virus are the same serotype, but their antigenicity and pathogenicity are different. Thus CS5 virus may be a new subtype of Ech_(06), i. e. Echo_(6-3), (Echo_(6-1,2) had been found according to literature).