Benign familial recurrent intrahepatic cholestasis |
| |
Authors: | Paul B Lesser MD |
| |
Institution: | (1) Department of Internal Medicine, Irwin Army Hospital, 66442 Fort Riley, KS;(2) Gastrointestinal Unit of the Medical Services, Massachusetts General Hospital, 02114 Boston, MA |
| |
Abstract: | Three new cases of benign familial recurrent intrahepatic cholestasis in a brother, sister, and mother are reported. These cases emphasize the familial nature of the disorder and the characteristic clinical findings of recurrent attacks, cholestatic jaundice, pruritus with increases in the serum bilirubin, and increased alkaline phosphatase. A normal extrahepatic biliary tree was shown by dye studies, and liver biopsy showed central lobular cholestasis without any inflammation or necrosis. Liver function tests were normal between attacks. This condition must be differentiated from extrahepatic obstruction, parenchymal liver disease, drug-induced cholestatic disease, and other familial types of jaundice. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|