Homogeneous deuteriodeiodination of iodinated tyrosine in angiotensin‐I using synthesized triethyl[2H]silane and Pd(0) |
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| Authors: | Martin Holst Friborg Pedersen Lars Martiny |
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| Institution: | Hevesy Laboratory, Radiation Research Division, Ris?‐DTU, Technical University of Denmark, Frederiksborgvej 399, Dk‐4000 Roskilde, Denmark |
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| Abstract: | In our efforts to develop new reactions for the efficient labelling of peptides and proteins with tritium, we now report the use of silane hydrides together with homogenous Pd(0) catalysis for the protio‐ and deuteriodeiodination of an o‐iodo‐tyrosine containing peptide (angiotensin‐I) performed at room temperature. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | deuterium peptide hydrodehalogenation homogenious catalysis palladium |
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