Changes in fetal acid-base chemistries following tromethamine (THAM) or bicarbonate infusions into fetal circulation of amniotic fluid |
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| Authors: | A.Elmore Seeds John J.P. Schruefer John M. Bissonnette Henry S. Lim Andre E. Hellegers Paul D. Bruns |
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| Affiliation: | 1. Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine Baltimore, Maryland, USA;2. Department of Gynecology and Medicine, Georgetown University Washington, D. C., USA |
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| Abstract: | Direct infusions of equimolar quantities of bicarbonate and tromethamine into rhesus monkey fetal circulation near term resulted in roughly equivalent increases in fetal pH. However, intra-amniotic infusion of tromethamine was not followed by alkaline changes in the fetus and in most instances was followed by a progressive fetal acidosis. This sharply contrasts with previous experimental success in elevating fetal pH via amniotic fluid bicarbonate infusions. |
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