A rapid one‐step radiosynthesis of [11C]‐d‐threo‐methylphenidate |
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| Authors: | Matthew D Moran Alan A Wilson Winston T Stableford Min Wong Armando Garcia Sylvain Houle Neil Vasdev |
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| Institution: | 1. PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont., Canada M5T 1R8;2. Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ont., Canada M5T 1R8 |
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| Abstract: | Carbon‐11 labelled d‐threo‐methylphenidate (11C]‐(1)), a radiopharmaceutical commonly used to image the dopamine transporter, has been labelled in one step using 11C]‐methyl triflate. No protection of the nitrogen atom on the piperidine ring of d‐threo‐ritalinic acid·HCl was required, as O‐methylation was favored over N‐methylation by performing the methylation in buffered solutions which effectively protonate and protect the amine functionality. The reaction was effectively carried out at room temperature in solution by captive solvent ‘LOOP’ methods or using conventional glass vials. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | PET carbon‐11 methyl triflate methylphenidate |
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