Allergy and glioma risk: Test of association by genotype |
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| Authors: | Sara E. Dobbins Fay J. Hosking Sanjay Shete Georgina Armstrong Anthony Swerdlow Yanhong Liu Robert Yu Ching Lau Minouk J. Schoemaker Sarah J. Hepworth Kenneth Muir Melissa Bondy Richard S. Houlston |
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| Affiliation: | 1. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom;2. Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX;3. Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom;4. Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX;5. Division of Epidemiology, Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom;6. Division of Epidemiology and Public Health, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, United Kingdom |
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| Abstract: | Although epidemiological studies have suggested an association between atopy and glioma risk, these observations have been based on self‐reporting of allergic conditions raising the possibility that associations may be noncausal and arise as a consequence of bias, reverse causation or other artifacts. Genetic information provides an alternative approach to investigate the relationship avoiding such biases. We analyzed 1,878 glioma cases and 3,670 controls for variants at 2q12, 5q12.1, 11q13 and 17q21 that are associated with asthma or eczema risk at p < 5.0 × 10?7. The SNP rs7216389, which tags the 3′ flanking region of ORMDL3 at 17q21 and has been associated with childhood asthma, was correlated with increased glioma risk (OR = 1.10; 95% CI: 1.01–1.19). These data provide evidence for a correlation between asthma susceptibility and glioma risk and illustrate the value of using genetics as an investigative tool for developing etiological hypotheses. |
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| Keywords: | allergy asthma atopy glioma polymorphism risk |
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