High‐grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: Report of a case with cytomorphologic and immunocytologic analysis |
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| Authors: | Yoshiki Ohta PhD CT Takao Suzuki PhD CT Tomoko Kojima CT Tetsuya Mikogami MD Mutsuko Omatsu MD Shigeharu Hamatani MD Akira Shiokawa MD Miki Kushima MD Hidekazu Ota MD |
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| Institution: | 1. Department of Pathology, Showa University Northern Yokohama Hospital, Kanagawa, Japan;2. Histochemical Laboratory, Showa University Fujigaoka Hospital, Kanagawa, Japan;3. Department of Pathology, Showa University Hospital, Tokyo, Japan;4. Second Department of Pathology, Showa University, Tokyo, Japan |
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| Abstract: | We report a case of high‐grade endometrial stromal sarcoma with cytological and immunocytochemical findings. Cytologically, major tumor cells showed round‐to‐short spindle shapes with round‐ to oval‐shaped nuclei and moderately abundant delicate cytoplasm. Tumor cells with tapered shapes and eccentric nuclei were also observed. A few spindle cells having enlarged cigar‐shaped nuclei with conspicuous nucleoli and delicate wispy cytoplasm, which resembled leiomyosarcoma, were intermingled. One rhabdomyoblast cell with both α‐sarcomeric muscle actin and myoglobin was also observed. Most of the tumor cells, including the leiomyosarcomatous spindle cells, were positive for CD10, and negative for desmin and h‐caldesmon. Accordingly, when relatively monotonous round‐to‐short spindle tumor cells and taper‐shaped tumor cells are observed in the female genital tract, high‐grade endometrial stromal sarcoma should be considered in the differential diagnosis. Immunocytochemistry contributed to the correct diagnosis. This case was high‐grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | endometrial stromal sarcoma smooth muscle rhabdomyoblast CD10 |
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