Synthesis of carbon‐14 labeled pyraoxystrobin,a novel fungicide

SYP‐3343, (E)‐2‐(2‐((3‐(4‐chlorophenyl)‐1‐methyl‐1H‐pyrazole‐5‐yloxy)methyl)) phenyl)‐3‐methoxyacrylate, is a novel fungicide with broad‐spectrum and high activity against fungi. In this paper, radioactive pyraoxystrobin, labeled in the pyrazole ring system was achieved from ¹⁴C labeled 4‐chlorobenzoic acid through substitution, cyclization, and condensation, in an overall chemical and radiochemical yield of 44%. The chemical and radiochemical purity of the title compound was 98.5% and 98.2%, respectively. This labeled SYP‐3343 was used as a radiotracer for metabolism, toxicology, mode of action, and other environmental studies. Copyright © 2011 John Wiley & Sons, Ltd.