Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex |
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Authors: | Roy Mukamel Yuval Nir Michal Harel Amos Arieli Rafael Malach Itzhak Fried |
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Institution: | 1. Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, California;2. UCLA Ahmanson‐Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, California;3. Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, California;4. Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel;5. Department of Psychiatry, University of Wisconsin, Madison, Wisconsin;6. Functional Neurosurgery Unit, Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel;7. Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, California |
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Abstract: | The effect of stimulus modulation rate on the underlying neural activity in human auditory cortex is not clear. Human studies (using both invasive and noninvasive techniques) have demonstrated that at the population level, auditory cortex follows stimulus envelope. Here we examined the effect of stimulus modulation rate by using a rare opportunity to record both spiking activity and local field potentials (LFP) in auditory cortex of patients during repeated presentations of an audio‐visual movie clip presented at normal, double, and quadruple speeds. Mean firing rate during evoked activity remained the same across speeds and the temporal response profile of firing rate modulations at increased stimulus speeds was a linearly scaled version of the response during slower speeds. Additionally, stimulus induced power modulation of local field potentials in the high gamma band (64–128 Hz) exhibited similar temporal scaling as the neuronal firing rate modulations. Our data confirm and extend previous studies in humans and anesthetized animals, supporting a model in which both firing rate, and high‐gamma LFP power modulations in auditory cortex follow the temporal envelope of the stimulus across different modulation rates. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc. |
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Keywords: | human auditory cortex spiking activity local field potentials (LFP) |
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