Follow-up of prostaglandin plasma levels after acute myocardial infarction |
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| Authors: | T Friedrich J Lichey S Nigam M Priesnitz K Wegscheider |
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| Institution: | 1. Mayo Clinic, Rochester, MN;2. Brigham and Women’s Hospital, Boston, MA;3. Mount Sinai Hospital, Icahn School of Medicine, New York, NY;4. Duke University Medical Center and Duke Heart Center, Durham, NC;5. Massachusetts General Hospital, Boston, MA;6. Boston University School of Medicine, Boston, MA;7. Indiana University School of Medicine, Indianapolis, IN;8. Duke Clinical Research Institute, Durham, NC;1. 1st Cardiology Clinic, ‘Hippokration’ General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece;2. National and Kapodistrian University of Athens, Department of Applied Physics, Faculty of Physics, Athens, Greece;3. Molecular and Clinical Sciences Research Institute, St. George''s University of London, London, United Kingdom |
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| Abstract: | Prostaglandin plasma levels are elevated in patients with transient myocardial ischemia. We measured 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and thromboxane (B2(TXB2) in venous blood of 32 patients with myocardial infarction on the first, third, and seventh days. TXB2 and 6-keto-PGF1 alpha levels in these patients (up to 117 +/- 237 pg/ml and 96 +/- 105 pg/ml mean +/- SD, respectively) differed significantly from levels in normal control subjects (10 +/- 12 pg/ml and 4 +/- 7 pg/ml mean +/- SD, respectively) (p less than 0.01). Prostaglandin values remained elevated from day 1 through day 7. In most patients, 6-keto-PGF1 alpha levels prevailed over those of TXB2. In a subgroup suffering from cardiac arrhythmias, the ratio of 6-keto-PGF1 alpha/TXB2 was inverse. It is concluded that prostaglandin generation is increased for at least 7 days after myocardial infarction. A disturbed ratio of 6-keto-PGF1 alpha/TXB2 in favor of the latter might be associated with cardiac arrhythmias in myocardial infarction. |
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