The influence of dietary fat on insulin resistance |
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Authors: | Jennifer C Lovejoy |
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Institution: | (1) Women's Nutrition Research Program, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, 70808 Baton Rouge, LA, USA |
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Abstract: | Dietary fat has been implicated in the development of insulin resistance in both animals and humans. Most, although not all,
studies suggest that higher levels of total fat in the diet result in greater whole-body insulin resistance. Although, in
practice, obesity may complicate the relationship between fat intake and insulin resistance, clinical trials demonstrate that
high levels of dietary fat can impair insulin sensitivity independent of body weight changes. In addition, it appears that
different types of fat have different effects on insulin action. Saturated and certain monounsaturated fats have been implicated
in causing insulin resistance, whereas polyunsaturated and omega-3 fatty acids largely do not appear to have adverse effects
on insulin action. Given the importance of insulin resistance in the development of diabetes and heart disease, establishing
appropriate levels of fat in the diet is an important clinical goal. |
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