发热患者C-反应蛋白、内毒素检测的临床分析

目的探讨发热患者早期C-反应蛋白(CRP)和内毒素水平测定的临床价值。方法采用回顾性调查分析,对医院2005年1-12月中81例发热患者(其中细菌性肺炎患者48例,上呼吸道细菌感染33例)的CRP和内毒素水平进行分析。结果在81例细菌性感染的患者中,肺炎组患者的内毒素水平明显高于上呼吸道感染患者,两组间差异有统计学意义(P<0.01);但CRP水平两组间差异无统计学意义。结论检测血浆内毒素含量有助于早期判断感染的严重程度,有利于临床合理利用抗菌药物和及时对症处理;尤其是在发热门诊,对患者的早期诊断、治疗上,内毒素水平的测定将有极大的帮助;CRP虽然可以协助区分细菌和病毒的感染,但是CRP不适合作为判断细菌感染患者严重程度的参考指标。

CRP Detection and Endotoxin Inspection in Fever Clinic: Their Clinical Significance

OBJECTIVE To investigate the changes in and clinical significance of C-reactive protein(CRP) and endotoxin in patients who are firstly examined in fever clinic.METHODS To review and study the results of CRP and endotoxin from 81 patients(including 48 patients who were diagnosed as bacterial pneumonia and 33 patients who were diagnosed as a cold) in fever clinic of our hospital in 2005.RESULTS In 81 bacterial infection patients, the analysis indicated the levels of endotoxin between the pneumonia patients and the patients with a cold had significant difference.And the levels in the first group were significantly higher than in the latter one.The levels of CRP had no difference in two groups.CONCLUSIONS The result indicates plasma endotoxin detection helps to determine the early diagnosis of serious infection.It is also of significance to select antibacterial rationally and handle syndrome in time.In fever clinic,the levels of endotoxin may be a method to help diagnosis and treatment.CRP could be help to estimate the bacterial infection or virus infection,but it could not adjudge the seriousness in bacterial infection.