阿维A联合中药泡浴治疗掌跖部慢性角化性湿疹疗效观察

目的 探讨阿维A联合中药泡浴治疗掌跖部慢性角化性湿疹的疗效.方法 68例患者按就诊顺序随机分为2组.治疗组36例口服阿维A 20mg,午餐时顿服,效果不显著时加量至30 mg,皮损消退后改为10 mg维持,联合中药泡浴;对照组32例口服依巴斯汀10 mg,1次/d,联合中药泡浴.2组均外擦曲安缩松尿素软膏,2次/d,疗程均为4周.结果 对照组与治疗组各有2例患者退出观察.对照组有效率60.0%（18/30）,治疗组为94.1%（32/34）,治疗组24例出现口唇干燥,15例出现皮肤脱屑、皮肤干燥,9例出现皮肤瘙痒,ALT升高3例,AST升高2例,总胆固醇升高3例,胃肠道不适5例,对照组2例轻度嗜睡.上述所有症状经对症处理和停药后均恢复正常,未影响治疗.结论 阿维A联合中药泡浴治疗掌跖部慢性角化性湿疹疗效较明显.

Clinical observation of acitretin combined with traditional Chinese herbs bath for the treatment of palmoplantar chronic keratotic eczema

Objective To investigate the efficacy of acitretin combined with traditional Chinese herb bath for the treatment of palmoplantar chronic keratotic eczema.Methods Totally 68 patients were randomly divided into two groups:treatment group was treated with oral acitretin and traditional Chinese herbs bath and the control group WaS treated with oral ebastine and traditional Chinese herb bath.The two groups were both treated with triameinolone acetonide et urea ointment.Results The efficaey rate in the treatment group Was 94.12%and it was 60%in the control group(P＜0.05).Conclusion Aeitretin combined with traditional Chinese herbs bath is effective for the treatment of palmoplantar chronic keratotic.