“心脉隆”抗野百合碱性肺动脉高压的作用及机制探讨

目的观察心脉隆注射液抗野百合碱（MCT）致大鼠肺动脉高压（PH）及对血管内皮舒缩因子内皮素（ET）和一氧化氮（NO）含量变化和影响。方法给SD大鼠一次腹腔注射MCT60mg／kg，复制PH模型，3周后用心脉隆注射液进行治疗，连续8天，然后用孙波法测定肺动脉压，用放免测定法和比色分析法分别测定血浆中ET及NO的含量。结果MCT所致大鼠肺动脉高压和右心室肥大模型效果确切，平均肺动脉压升高、右心室／心脏重量比、肺湿／干重比值增大，与对照组相比，JP〈0．001（20．47±1．22）：（11．02±1．21）]；使用心脉隆治疗后，肺动脉压有所降低，与模型组相比P〈0．05（12．31±1．12）：（18．47±1．32），血浆中ET明显升高，NO下降（P〈0．01）。结论MCT造成肺动脉高压模型效果确切，心脉隆注射液对MCT所致的肺动脉高压有一定的对抗作用，同时使血浆中NO明显升高而ET下降，说明心脉隆注射液降低肺动脉高压与其保护血管内皮作用有关。

Experimental Study of the XML Injection Antagonizing Rat Pulmonany Hypertension by Monocrotaline.

Objective To observe the effect of xinmailong（XML） injection on rat pulmonary hypertension（PH） by monoerotaline （MCT）. Methods SD rats were given a single intraperitoneal injection of MCT with 60mg/kg to induce the mold of PH. Three weeks later,these rats were treated with XML for 8d,and then PH was measured using Sun Puo＇ s method. Results PH and right ventricle hypertrophy model had been set up successfully by MCT. The ratio of wet weight （wW） and dry weight （dW） of the lung increased with P 〈 0. 001 （20.47± 1.32：11.02± 1.2） ]. The rat pulmonary avevage pressure of XML group also was lower than that of model group with P 〈0. 05 （ 12.31 ± 1. 12：18.47± 1.32 ） ]. Conclusion Treatment with XML injection may reduce the development of MCT pulmonary hypertension.