| 含2-甲基-5-硝基咪唑的环丙沙星衍生物的合成 |
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| 引用本文： | 叶发青,陈莉,袁昕,叶松. 含2-甲基-5-硝基咪唑的环丙沙星衍生物的合成[J]. 咸宁医学院学报, 2002, 16(4): 262-265 |
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| 作者姓名： | 叶发青 陈莉 袁昕 叶松 |
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| 作者单位： | [1]温州医学院药学院化学教研室，浙江温州325027 [2]咸宁医学院药学系药物化学教研室 |
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| 基金项目： | 湖北省教育厅重点课题资助项目 (98B0 33) |
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| 摘 要： | 目的 研究N－乙基－2－甲基－5－硝基咪唑的环丙氯哌酸及其酯的衍生物的合成。方法 采用2－甲基－5－硝基咪唑、环丙氟哌酸等物质为原料，通过亲核取代、酯化进行合成。结果 得到标题化合物。结论 标题化合物的结构经IR、MS、^1H-NMR和元素分析所确证。
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| 关 键 词： | 2－甲基－5－硝基咪唑 环丙沙星 衍生物 合成 |
| 文章编号： | 1008-0635(2002)04-0262-04 |
| 修稿时间： | 2002-03-11 |
Synthesis of Ciprofloxacin Derivatives Containing 2-Methyl-5-Nitroimidazol |
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| YE Fa-qing ,CHEN Li,YUAN Xin,et al. Synthesis of Ciprofloxacin Derivatives Containing 2-Methyl-5-Nitroimidazol[J]. Journal of Xianning Medical College, 2002, 16(4): 262-265 |
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| Authors: | YE Fa-qing CHEN Li YUAN Xin et al |
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| Affiliation: | YE Fa-qing 1,CHEN Li,YUAN Xin,et al |
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| Abstract: | Objective To study the synthesis of ciprofloxacin derivatives containing 2-methyl-5-nitroimidazol.Methods Ciprofloxacin derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin via nucleophilic substitution and esterifying.Results Ciprofloxacin derivatives containing 2-methyl-5-nitroimidazol had been synthesized.Conclusion The structure of these new compounds have been examined and confirmed by IR? 1 H-NMR?MS spectra as well as elementary analysis. |
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| Keywords: | Ciprofloxacin derivatives Prodrug Imidaxole |
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