Peritoneal endotoxicosis,morphology, and morphogenesis of biosystem involvement in experimental animals

Experimental acute peritonitis was induced by single and repeated injections of 1.5–3% fecal autosuspension in the abdominal cavity of white rats. The blood content of medium-weight molecular proteins, which increases 1.5-2-fold during the course of entry of toxic products into the blood over 1–3 days, was measured. Examination of the vascular system and parenchymatous elements of many organs helped reveal three morphogenetic mechanisms of their injury: hyperfunction of cells, followed by their depletion and death; the direct action of toxic products on membranous structures of cells due to severe impairment of the histohematic barrier at the level of the microcirculation; the destructive effect of hypoxia due to the development of the disseminated intravascular coagulation syndrome. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 12, pp. 636–639, December, 1994 Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences