姜黄素对大鼠脑出血后血肿周围脑组织含水量的影响

目的:探讨姜黄素对大鼠脑出血(ICH)后脑水肿形成的影响.方法:将120只SD大鼠随机分为姜黄素治疗组(Cur治疗组,n=40)、脑出血对照组(ICH对照组,n=40)和假手术组(n=40).每组分为手术前、术后6h、12h、24h、48h、72h、96h、120h等8个时点,每个时点5只大鼠.采用立体定向自体血注入大鼠尾状核建立ICH模型,观察各组术前及术后各时点神经功能障碍评分和血肿周围脑组织含水量变化.结果:Cur治疗组术后12～120h各时点神经功能障碍评分均高于ICH对照组(P＜.05).Cur治疗组术后24～96h各时点含水量均低于ICH对照组(＜0.05).Cur治疗组术后各时点神经功能障碍评分与相应血肿周围脑组织含水量呈负相关(r=-0.791,P＜0.001).结论:Cur治疗能改善ICH大鼠神经功能,减轻脑水肿.Cur减轻ICH后脑损伤可能与减轻脑水肿有关.Cur对大鼠ICH后脑水肿及脑损伤可能有保护作用.

EFFECT OF CURCUMIN ON WATER CONTENT IN PERIHEMATOMA FOLLOWING INTRACEREBRAL HEMORRHAGE IN RATS

Objective:To explore the effect of curcumin on brain edema after intracerebral hemorrhage(ICH).Methods:In this study,120 SD rats were divided into curcumin treating group(n=40),ICH control group(n=40)and sham operation group(n=40).Intracerebral hemorrhage was iuduced in rats by injecting autologous blood into the left caudate and water content was examined in perihematoma at various stages using wet-dry weight measurement.Neurobehavioral outcome was assessed preoperation and 6h,12h,24h,48h,72h,96h,120h postoperation.Results:Neurobehavioral scores at 12~120h in Cur treating group were higher than those in ICH control group(P<0.05).Compared with ICH group,water contents in perihematoma at 24~96h in Cur treating group were significantly decreased(P<0.05).Neurobehavioral scores at various stages postoperation in Cur treating group were significantly negatively correlated with water contents(r=-0.791,P<0.001).Conclusion:Treatment with Cur in rat models of intracerebral hrmorrhage increased neurobehavioral scores and reduced brain edema.Protective effect of Cur on brain injury following intracerebral hemorrhage may result from brain edema rdeuction.These results demonstrated the protective effect of Cur on brain damage following intracerebral hemorrhage in rats.