Conserved mutation of Epstein-Barr virus-encoded BamHI-A Rightward Frame-1 (BARF1) gene in Indonesian nasopharyngeal carcinoma |
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| Authors: | Susanna H Hutajulu Eveline K Hoebe Sandra AWM Verkuijlen Jajah Fachiroh Bambang Hariwijanto Sofia M Haryana Servi JC Stevens Astrid E Greijer Jaap M Middeldorp |
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| Institution: | (1) Faculty of Medicine/Dr. Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia;(2) Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands;(3) Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands |
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| Abstract: | Background BamHI-A rightward frame-1 (BARF1) is a carcinoma-specific Epstein-Barr virus (EBV) encoded oncogene. Here we describe the
BARF1 sequence diversity in nasopharyngeal carcinoma (NPC), other EBV-related diseases and Indonesian healthy EBV carriers
in relation to EBV genotype, viral load and serology markers. Nasopharyngeal brushings from 56 NPC cases, blood or tissue
from 15 other EBV-related disorders, spontaneous B cell lines (LCL) from 5 Indonesian healthy individuals and several prototype
EBV isolates were analysed by PCR-direct sequencing. |
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