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Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old |
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| Authors: | Dilek Colak Muhammad A Chishti Al-Bandary Al-Bakheet Ahmed Al-Qahtani Mohamed M Shoukri Malcolm H Goyns Pinar T Ozand John Quackenbush Ben H Park Namik Kaya |
| Affiliation: | (1) Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;(2) Department of Medical Biochemistry/Obesity Research Center, King Saud University, Riyadh, Saudi Arabia;(3) Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;(4) Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;(5) Liver Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia;(6) Immorgene Concepts Ltd, Stockton-on-Tees, UK;(7) Duzen Laboratories, Istanbul, Turkey;(8) Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA;(9) The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA |
| Abstract: | BackgroundHepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths worldwide. It is often diagnosed at an advanced stage, and hence typically has a poor prognosis. To identify distinct molecular mechanisms for early HCC we developed a rat model of liver regeneration post-hepatectomy, as well as liver cells undergoing malignant transformation and compared them to normal liver using a microarray approach. Subsequently, we performed cross-species comparative analysis coupled with copy number alterations (CNA) of independent early human HCC microarray studies to facilitate the identification of critical regulatory modules conserved across species. |
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