| 前列腺癌患者CYP1A2 IVS4+43A/G基因型分析 |
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| 引用本文： | 葛京平,魏武,商学军,张征宇,许松,王东,高建平.前列腺癌患者CYP1A2 IVS4+43A/G基因型分析[J].中华男科学杂志,2007,13(11):1002-1004. |
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| 作者姓名： | 葛京平 魏武 商学军 张征宇 许松 王东 高建平 |
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| 作者单位： | 1. 南京军区南京总医院泌尿外科,江苏,南京,210002
2. 南京军区南京总医院解放军临床检验医学研究所,江苏,南京,210002 |
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| 摘 要： | 目的:应用TaqMan荧光定量技术,了解前列腺癌患者CYP1A2 IVS4+43A/G位点基因表型。方法:应用ABI Prism7300型荧光定量PCR仪,通过序列检测系统测定85例前列腺癌患者CYP1A2 IVS4+43A/G的各种基因型,并分析不同基因型患者与前列腺癌分化之间的相关性。结果:85例前列腺癌患者中CYP1A2 IVS4+43A/G位点基因表型为AA5例(5.9%),AG33例(38.8%),GG47例(55.3%)。且各基因表型与前列腺癌Gleason评分无明显相关性。结论:CYP1A2 IVS4+43A/G各基因表型与前列腺癌分化之间无明显相关性。
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| 关 键 词： | TaqMan荧光定量技术 前列腺癌 CYP1A2 IVS4+43A/G |
| 文章编号： | 1009-3591(2007)11-1002-03 |
| 修稿时间： | 2007年2月28日 |
Genotype Analysis of CYP1A2 IVS4 + 43A/G in Patients with Prostate Cancer |
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| GE Jing-ping,WEI Wu,SHANG Xue-jun,ZHANG Zheng-yu,XU Song,WANG Dong,GAO Jian-ping.Genotype Analysis of CYP1A2 IVS4 + 43A/G in Patients with Prostate Cancer[J].National Journal of Andrology,2007,13(11):1002-1004. |
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| Authors: | GE Jing-ping WEI Wu SHANG Xue-jun ZHANG Zheng-yu XU Song WANG Dong GAO Jian-ping |
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| Institution: | Department of Urology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. |
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| Abstract: | OBJECTIVE: To investigate the genotype of the single nucleotide polymorphisms(SNP) of CYP1A2 IVS4 + 43A/G in patients with prostate cancer by TaqMan allelic discrimination. METHODS: TaqMan SNP allelic discrimination was performed with the ABI 7300 system to detect the genotype of CYP1A2 IVS4 + 43A/G in 85 patients with prostate cancer. RESULTS: The genotypes of CYP1A2 IVS4 + 43A/G in the patients were as follows: AA subtype in 5 cases (5.9%), AG in 33 (38.8%), and GG in 47 (55.3%). Each subtype of CYP1A2 IVS4 + 43A/G was not correlated with the Gleason score of prostate cancer. CONCLUSION: There was no significant correlation between SNP of CYP1A2 and the differentiation of prostate cancer. |
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| Keywords: | CYP1A2IVS4 43A/G |
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