超敏C反应蛋白、纤维蛋白原与腔隙性脑梗死患者颈动脉粥样硬化程度的相关性分析

目的通过对腔隙性脑梗死患者超敏C反应蛋白(hsCRP)、纤维蛋白原(Fib)水平及颈动脉内-中膜厚度(IMT)的测定,探讨hsCRP、Fib与无高血压、糖尿病等高危因素的首发腔隙性脑梗死患者颈动脉粥样硬化程度的相关性。方法 186例住院的腔隙性脑梗死患者为实验组,根据IMT厚度分为研究A组34例(正常组)、研究B组62例(内-中膜增厚组)、研究C组90例(斑块组)三个亚组。100例健康者为对照组。两组均接收颈动脉超声检查,检测颈动脉内-中膜厚度(IMT);并对超敏C反应蛋白(hsCRP)、纤维蛋白原(Fib)水平与颈动脉硬化程度进行相关性分析。结果实验组hsCRP、Fib水平及IMT均高于对照组(P﹤0.01),各实验亚组间比较差异有统计学意义(P﹤0.01)。HsCRP、Fib水平与IMT呈线性相关(r=0.955,P=0.008;r=0.968,P=0.000),hsCRP与Fib亦呈线性相关(r=0.828,P=0.000)。结论 Fib及血清hsCRP参与了动脉粥样硬化的形成,并在无高血压等高危因素的腔隙性脑梗死首发者中起着重要作用。

Correlation analysis between the carotid artery arteriosclerosis of patients with lacunar infarct and the level of serum high-sensitivity C-reactive protein and fibrinogen

Objective To investigate the correlation between serum high-sensitivity C-reactive protein(hsCRP),fibrinogen(Fib) and the degree of carotid artery arteriosclerosis by detecting the level of hs-CRP,Fib and carotid intima-media thickness(IMT) in patients with lacunar infarct.Methods We chose 186 in-patients with lacunar infarct as the experimental group.They were divided into 3 subgroup according to the value of IMT: experimental group A(normal IMT,including 34 cases),experimental group B(increasing IMT,including 62 cases),experimental group C(atheromatous plaque,including 90 cases).Also,we chose 100 healthy persons as the control group.For both groups,the IMT(using carotid artery sonography) and the level of serum hsCRP,Fib was measured.Then,we analyzed the correlation between the degree of carotid artery arteriosclerosis and the serum level of hs-CRP,Fib.Results The value of hsCRP,Fib and IMT was higher in the experimental group than in the control group(P<0.01).The difference among the experimental subgroups was statistically significant(P<0.01).There was linear correlation between the level of hs-CRP,Fib and IMT(r=0.955,P=0.008;r=0.968,P=0.000).Conclusion HsCRP,Fib involve in the formation of athero-sclerosis and play an important role in the first-onset lacunar infarct patient without hypertension and other risk factors.