| PDGF-BB在人脑血管母细胞瘤中的表达及意义 |
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| 引用本文： | 刘敏,李嵩,张玉淼,刘春辉,石汉文.PDGF-BB在人脑血管母细胞瘤中的表达及意义[J].脑与神经疾病杂志,2012,20(6):411-412. |
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| 作者姓名： | 刘敏 李嵩 张玉淼 刘春辉 石汉文 |
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| 作者单位： | 河北医科大学第二医院康复科;中国人民解放军军械工程学院门诊部;河北医科大学第二医院急诊科 |
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| 基金项目： | 河北省科学技术研究与发展指导计划项目(112761154) |
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| 摘 要： | 目的研究血小板源生长因子B链的纯合二聚体(PDGF-BB)在人脑血管母细胞瘤和正常脑组织中的表达。方法应用链霉菌抗生物素蛋白-过氧化物酶法(S-P法),观察PDGF-BB在32例人脑血管母细胞瘤组织中的表达情况,并与10例正常脑组织作对照。结果 PDGF-BB在人脑血管母细胞瘤组织中的灰度值明显高于正常脑组织(P<0.01)。结论 PDGF-BB在脑血管母细胞瘤血管生成中起着重要作用,抗PDGF-BB治疗可能成为治疗脑血管母细胞瘤的新方法。
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| 关 键 词： | 血管母细胞瘤 血小板源生长因子 免疫组织化学 |
Clinic role and expression of platelet-derived growth factor B chain in hemangioblastoma |
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| LIU Min,LI Song,ZHANG Yu-miao,LIU Chun-hui,SHI Han-wen.Clinic role and expression of platelet-derived growth factor B chain in hemangioblastoma[J].Journal of Brain and Nervous Diseases,2012,20(6):411-412. |
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| Authors: | LIU Min LI Song ZHANG Yu-miao LIU Chun-hui SHI Han-wen |
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| Institution: | .Department of Rehabilitation,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
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| Abstract: | Objective To explore the expression and clinical significances of platelet-derived growth factor(PDGF) B chain in hemangioblastoma.Methods Applying Srteptavidin-Peroxidase(S-P) immunohistochemical technique,we performed examination and statistical research on the expression of PDGF in 32 cases of hemangioblastoma and 10 cases of normal brain tissue.Results In this study,there was obvious differencd in the expression of PDGF between hema-ngioblastoma and normal brain tissue(P<0.01).Conclusion Hemangiob-lastoma can secrete PDGF.Therapy of anti-PDGF could be a new method for the treatment of hemangioblastoma. |
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| Keywords: | Hemangioblastoma Platelet-derived growth factor(PDGF) B chain Immunohistochemistry |
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