四磨汤有效成分对慢性应激小鼠胃肠运动的影响

目的：观察四磨汤有效成分（槟榔碱、乌药醚内酯、橙皮苷及木香烃内酯）对慢性应激小鼠胃肠运动功能的影响。方法：将144只小鼠随机分为正常组（8只）和造模组（136只）,模型小鼠给予不可预知的慢性应激造模21d后随机分为模型组、四磨汤组及四磨汤成分组（15组）共17组;造模第15天起给药7d后,检测各组小鼠的胃肠运动功能。结果：模型组胃内残留率升高,小肠推进率降低,与正常组及四磨汤组比较差异均有统计学意义（P〈0.01）。四磨汤有效成分三药及四药组合组胃内残留率降低,小肠推进率升高,与模型组比较差异均有统计学意义（P〈0.05或P〈0.01）;而四磨汤有效成分单药组及两两组合组的胃内残留率和小肠推进率与四磨汤组比较仍具有统计学意义（P〈0.01）,与模型组比较差异均无统计学意义（P〉0.05）。结论：槟榔碱、乌药醚内酯、橙皮苷、木香烃内酯可能为四磨汤的有效物质基础,可不同程度改善慢性应激小鼠的胃肠运动功能。

Impact of Effective Substances of Simo Decoction on Gastrointestinal Movement of Mice under Chronic Stress

Objective： To observe effect of effective substances of Simotang （arecoline,linderane,hesperidin and costunolide） on gas-trointestinal motility function in mice under chronic stress. Methods： 144 mice were divided into normal group （n=8） and model group （n=136） . Model group was under unpredictable chronic stress,after 21d,divided to model group,Simo decoction group and 15 substances groups. 7days after medication,gastrointestinal motility were assessed. Results： The model group showed slower gastric empty- ing and slower intestinal propulsion compared with the normal group and the Simo decoction group （P0.01） . Three or four substance groups showed quicker gastric emptying,and small intestinal propulsion,compared with model group （P0.05 or P 0.01） . Single or two substance groups showed quicker gastric emptying and intestinal propulsive,compared with Simo decoction group （P0.01） ,but the difference was not significant compared with the model group（ P 0. 05） . Conclusion： Arecoline,linderane,hesperidin,costunolide are effective substance of Simo decoction,which can improve gastrointestinal motility function of mice with various degrees of chronic stress.