宣痹汤治疗急性痛风性关节炎116例疗效观察

目的：探讨宣痹汤治疗急性痛风性关节炎的临床疗效。方法：将急性痛风性关节炎发作期患者116例随机分为治疗组与对照组各58例,均予对症处理,治疗组加服宣痹汤,疗程2周,观察治疗前后血尿酸、红细胞沉降率及C-反应蛋白的变化,并对观察结果采用t检验、秩和检验进行统计学分析。结果：对照组治疗后与治疗前比较,血尿酸、红细胞沉降率及C-反应蛋白指标均降低（t=7.7097,P〈0.05;t=29.1362,P〈0.05;t=10.2993,P〈0.05）,所有指标前后比较差异有统计学意义;对照组仅有C-反应蛋白明显降低（t=24.0192,P〈0.05）,指标前后比较差异有统计学意义,而血尿酸、红细胞沉降率的变化无统计学意义（t=1.9309,P〉0.05;t=1.7380,P〉0.05）。治疗2个疗程后治疗组与对照组比较,血尿酸、红细胞沉降率和C-反应蛋白2组之间差异有统计学意义（Uc=4.0915,P〈0.05;Uc=2.4031,P〈0.05;Uc=7.4011,P〈0.05）,2组比较,治疗组比对照组对降低血尿酸、红细胞沉降率及C反应蛋白水平更为显著。临床疗效比较,治疗组总有效率96.5%,对照组总有效率86.5%,且治疗组治愈率、好转率均大于对照组,2组疗效比较差异有统计学意义（9.28,P〈0.01）,治疗组明显优于对照组。结论：宣痹汤治疗急性痛风性关节炎疗效确切,治疗组明显优于对照组,且随访6个月,复发率低。

Clinical observation on Xuanbi Decoction Treating 116 Cases of Acute Gouty Arthritis

Objective： To explore the clinical curative effect of Xuanbi decoction treating acute gouty arthritis. Methods： One hundred and sixteen patients with acute gouty arthritis disease were randomly divided into treatment group （ n = 58） and control group （n= 58） . Patients in both group received symptomatic treatment at the same time and patients in treatment group were given extra administration of Xuanbi decoction for two treatment courses. Blood Uric Acid,ESR （erythrocyte sedimentation rate） and （ CRP ） C-reaction Protein before and after the treatment were observed. Statistical analysis was also implemented by using＂t＂test,rank sum test and＂χ 2 ＂test on observation results. Results： There were reduction of Blood Uric Acid,ESR （erythrocyte sedimentation rate） and （ CRP） C-reaction Protein （ t = 7. 7097,P 0. 05; t = 29. 1362,P 0. 05; t = 10. 2993,P0.05） in treatment group after treatment,and all items hadstatistic significance; For the control group,there was reduction of （ CRP） C-reaction Protein after treatment （t= 24. 0192,P 0. 05） , and the item had statistic significance. But there were no reduction of blood Uric Acid or ESR（ erythrocyte sedimentation rate） （t = 1. 9309,P 0. 05; t = 1. 7380,P 0. 05） ,and neither items had statistic significance. After two courses of treatment,the treatment group showed better results in affecting Blood Uric Acid,ESR（ erythrocyte sedimentation rate） ,C-reaction Protein（ CRP） than control group （Uc =4. 0915,P 0. 05; Uc =2. 4031,P 0. 05; Uc =7. 4011,P 0. 05） . The ORR （overall response rate） of treatment group was 96. 5% while that of control group was 86. 5% ,and the cure rate and improvement rate of treatment group were higher than those of control group. There was statistically significant difference between the two groups （ χ 2 = 9. 28,P 0. 01） . Conclusion： Xuanbi decoction has definite therapeutic effect for the acute gouty arthritis disease. The treatment group showed better results than the control group,and 6-month follow-up showed low recurrence rate.