Amylase producing lung cancer |
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Authors: | Toshio Morohoshi Naobumi Nakamura Kazunori Hayashi Mikio Kanda |
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Affiliation: | (1) Ist Department of Pathology, Showa University School of Medicine, Hatanodai 1-5-8 Shinagawa-ku, 142 Tokyo, Japan;(2) Tokyu Hospital, Kitasenzoku 1-45-6, Ohota-ku, 145 Tokyo, Japan;(3) Present address: Institut für Pathologie der Universität Hamburg, Martinistraße 52, UKE, D-2000 Hamburg 20, Germany |
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Abstract: | Summary A case of the lung cancer associated with marked elevation of serum (7820 IU/l) and of urinary amylase (2225 IU/l) was autopsied. Material was examined histopathologically, electronmicroscopically and biochemically. The pulmonary tumor tissues showed histological pattern of papillary adenocarcinoma. In addition to the small round bodies which were very similar to secretory glanules, many large round bodies were noticed, diffusely distributed in the tumor cell. These large round bodies ranged from 0.2 to 0.7 m in diameter and showed a lamellar or annular pattern. The soluble phase of the homogenized pulmonary tumor tissues had an amylase level of 11,300 IU/g of protein, which consisted of S-type isoamylase with minor components. Cholesterol, triglyceride and phospholipid were also present at greater concentration in the tumor tissue than the normal pulmonary tissue. The large round bodies appeared too, to be amylase including bodies from the electronmicroscopical and biochemical findings. |
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Keywords: | Lung Lung neoplasms Amylase Neoplasm proteins |
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