| 7－［4－（2，4－二氨基喹唑啉－6－基）哌嗪－1－基］－6－氟喹诺酮类化合物的合成和抗菌作用 |
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| 引用本文： | 刘庆,周伟澄,余爱珍,张庆文,张秀平. 7－［4－（2，4－二氨基喹唑啉－6－基）哌嗪－1－基］－6－氟喹诺酮类化合物的合成和抗菌作用[J]. 中国医药工业杂志, 1996, 0(3) |
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| 作者姓名： | 刘庆 周伟澄 余爱珍 张庆文 张秀平 |
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| 作者单位： | 上海医药工业研究院 |
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| 摘 要： | 合成了６个７－［４－（２，４－二氨基喹唑啉－６－基）哌嗪－１－基］－６－氟－１，８－二取代－１，４－二氢－４－氧代喹啉－３－羧酸及其类似物。对２０株细菌的体外抗菌试验结果表明，它们对革兰阴性菌无明显作用，对某些革兰阳性菌的作用较好。
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| 关 键 词： | 二氨基喹唑啉，氟喹诺酮，抗菌作用 |
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 7-[4-(2,4-DIAMINO-6-QUINAZOLINYL)-1-PIPERAZINYL]-6-FLUOROQUINOLONE DERIVATIVES |
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| LIU Qing, ZHOU Wei-Cheng, YU Ai-Zhen, ZHANG Qing-Wen,ZHANG Xiu-Ping. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 7-[4-(2,4-DIAMINO-6-QUINAZOLINYL)-1-PIPERAZINYL]-6-FLUOROQUINOLONE DERIVATIVES[J]. , 1996, 0(3) |
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| Authors: | LIU Qing ZHOU Wei-Cheng YU Ai-Zhen ZHANG Qing-Wen ZHANG Xiu-Ping |
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| Abstract: | Some 7-[4-(2,4-diamino-6-quinazolinyl-1-piperazinyl]-6-fluoro-1,8-disubstituted-1,4-dihydro-4-oxoquinoline-3-car acids and the analogues were synthesized and they possessed good antibacterial activity against some gram-positive bacteria in vitro but had no sisrnificant effect against gram-positive bacteria. |
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| Keywords: | diaminoquinazolines fluoroquinolones antibacterial activity |
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