Immunization with recombinant Plasmodium yoelii merozoite surface protein 4/5 protects mice against lethal challenge |
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| Authors: | Kedzierski L Black C G Coppel R L |
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| Affiliation: | Department of Microbiology, Monash University 3800, Victoria, Australia. |
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| Abstract: | Plasmodium yoelii merozoite surface protein 4/5 (PyMSP4/5), expressed as a recombinant protein, was highly effective at protecting mice against lethal challenge with P. yoelii. There was a significant correlation between prechallenge antibody levels and peak parasitemia, suggesting that the homologues of PyMSP4/5 in Plasmodium falciparum are promising components of a subunit vaccine against malaria. |
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