| 流行性腮腺炎WM84株疫苗的有效免疫反应 |
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| 引用本文： | 魏树源,钟绍基,李秀兰.流行性腮腺炎WM84株疫苗的有效免疫反应[J].华中科技大学学报(医学版),2000,29(6):529-530. |
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| 作者姓名： | 魏树源 钟绍基 李秀兰 |
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| 作者单位： | 武汉生物制品研究所腮腺炎室，武汉 430060 |
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| 摘 要： | 流行性腮腺炎WM84减毒株（以下称流腮WM84株）经原代鸡胚成纤维细胞传代获得，研究表明该毒株反应轻微，免疫原性好，无神经毒性。8个月至2岁儿童流行病学观察结果表明流行性腮腺炎抗体阳转率达96.4%～100%，几何平均滴度（GMT）4.5～6.2，降低发病率87.5%，证明流腮WM84株疫苗对流行性腮腺炎有很好的预防作用。
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| 关 键 词： | 流行性腮腺炎减毒活疫苗 流腮WM84减毒株 免疫原性 血凝抑制试验 |
| 修稿时间： | 2000年1月15日 |
Effective Immune Response of Live Attenuated Mumps Strain WM84 |
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| Wei Shuyuan,Zhong Shaoji,Li Xiulan Wuhan Institute of Biological Products,Wuhan.Effective Immune Response of Live Attenuated Mumps Strain WM84[J].Journal of Huazhong University of Science and Technology(Health Sciences),2000,29(6):529-530. |
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| Authors: | Wei Shuyuan Zhong Shaoji Li Xiulan Wuhan Institute of Biological Products Wuhan |
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| Institution: | Wei Shuyuan,Zhong Shaoji,Li Xiulan Wuhan Institute of Biological Products,Wuhan 430060 |
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| Abstract: | An attenuated mumps strain WM84 was obtained by serial passages in primary chicken embryo cell culture. The isolated strain showed a slight reactogenicity, a good immunogenicity and fewer nerovirlence. The results of epidemic observation of strain WM84 vaccine in the children with 8 month to 2 year demonstrat- ed that the seroconverted rate was up to 96 % to 100 %, GMT 4.5 to 6.2 and the reduced incidence by 87. 5 %. All of these data strongly suggested that strain WM84 vaccine was good prophylactic against mumps. |
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| Keywords: | live attenuated mumps strain WM84 live attenuated mumps strain WM84 vaccine im- munogenicity |
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