Treatment of dyskeratosis congenita with Granulocyte Colony-Stimulating Factor and Erythropoietin |
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| Authors: | Blanche P Alter Frank H Gardner & Robert E Hall |
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| Institution: | Division of Pediatric Hematology/Oncology, Department of Pediatrics; Division of Hematology/Oncology, Department of Medicine, University of Texas Medical Branch, Galveston, Texas,; Department of Medicine, Hematology/Oncology, University of Tennessee Medical Center at Knoxville, Knoxville, Tennesse, U.S.A. |
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| Abstract: | Aplastic anaemia is both frequent and difficult to manage in patients with dyskeratosis congenita (DC). We recently treated a 23-year-old male for a year with granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Ep), with an excellent neutrophil response, and a transient effect on haemoglobin levels. G-CSF alone or combined with other cytokines may provide at least a partial effect in pancytopenic patients with DC. |
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| Keywords: | dyskeratosis congenita G-CSF erythropoietin aplastic anaemia |
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