| PSCA基因多态性与青海地区藏族胃癌遗传易感性的初步研究 |
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| 引用本文： | 沈国双,张成武,赵久达,耿排力,窦拉加,张双元,马德寿,李国元. PSCA基因多态性与青海地区藏族胃癌遗传易感性的初步研究[J]. 青海医学院学报, 2011, 32(3): 169-171 |
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| 作者姓名： | 沈国双 张成武 赵久达 耿排力 窦拉加 张双元 马德寿 李国元 |
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| 作者单位： | 1. 青海大学附属医院
2. 青海大学医学院 |
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| 基金项目： | 青海大学中青年科研基金资助项目(编号:2009-QY-17) |
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| 摘 要： | 目的 初步研究PSCA基因多态性与青海地区藏族胃癌遗传易感性.方法 收集60例藏族胃癌患者与60例健康人群的外周血标本,提取基因组DNA,采用dHPLC方法进行PSCA基因rs2976392位点分型.结果 PSCA基因rs2976392位点3种基因型G/A、A/A、G/G在胃癌病例组中的频率分别为51.67％、8.33...
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| 关 键 词： | PSCA 基因多态性 胃癌 |
A STUDY OF RELATIONSHIP BETWEEN PSCA GENE POLYMORPHISMS AND SUSCEPTIBILITY TO TIBETAN GASTRIC CANCER IN QINGHAI AREA |
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| Sheng Guoshuang,Zhang Chengwu,Zhao Jiuda,Geng Paili,Dou Lajia,Zhang Shuangyuan,Ma Deshou,Li Guoyuan. A STUDY OF RELATIONSHIP BETWEEN PSCA GENE POLYMORPHISMS AND SUSCEPTIBILITY TO TIBETAN GASTRIC CANCER IN QINGHAI AREA[J]. Journal of Qinghai Medical College, 2011, 32(3): 169-171 |
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| Authors: | Sheng Guoshuang Zhang Chengwu Zhao Jiuda Geng Paili Dou Lajia Zhang Shuangyuan Ma Deshou Li Guoyuan |
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| Affiliation: | Sheng Guoshuang1,Zhang Chengwu1,Zhao Jiuda1,Geng Paili2,Dou Lajia1,Zhang Shuangyuan1,Ma Deshou1,Li Guoyuan1 (1.Qinghai University Hospital,2.Qinghai University Medical College) |
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| Abstract: | Objective To investigate the polymorphisms of PSCA gene allele rs2976392 and the relationship between the genotype of PSCA and susceptibility to Tibetan gastric cancer in Qinghai area.Methods Genotypes were determined by PCR-based denaturing high-performance liquid chromatography analysis and direct DNA sequencing in 60 Tibetan patients with gastric cancer and 60 controls recruited in Qinghai area.Results In patients and normal controls,the frequency of G/A was 51.67%31(31/60) and 43.33%(26/60),respectively... |
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| Keywords: | PSCA Gene Polymorphism Gastric cancer |
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