| 八味獐芽菜散对小鼠急性肝损伤的保护作用 |
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| 引用本文： | 那玉清,保守魁. 八味獐芽菜散对小鼠急性肝损伤的保护作用[J]. 青海医学院学报, 2011, 32(4): 253-255 |
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| 作者姓名： | 那玉清 保守魁 |
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| 作者单位： | 1. 青海省互助县人民医院
2. 青海大学医学院 |
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| 摘 要： | 目的了解八味獐芽菜散对CCl4所致小鼠急性肝损伤的保护作用，探讨其保护机制。方法40只昆明种健康小鼠随机分为四组。八味獐芽菜散组予八味獐芽菜散（450mg／kg·d）灌胃，连续7d；联苯双酯组予联苯双酯（11．3mg／kg·d）灌胃，连续7d；空白对照组与模型组予等量蒸馏水灌胃，连续7d。除空白对照组外，其他三组于第7d用10％CCl4花生油溶液（10mL／kg）于腹腔注射，24h后采集血样，测定小鼠血清ALT、TNF-α、IL-10。结果八味獐芽菜散组与模型组比较，ALT、TNF-α水平明显降低（P〈0．01），而IL—10水平升高（P〈0．01），但与联苯双酯组比较无显著性差异。结论八味獐芽菜散具有抗CCl4肝损伤的作用，其机理可能与提高IL-10、抑制TNF-α水平有关。
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| 关 键 词： | 小鼠 急性肝损伤 八味獐芽菜散 TNF-α IL-10 |
PROTECTIVE EFFECTS OF EIGHT KINDS OF SWERTIA POWDER ON ACUTE LIVER DAMAGE IN MICE |
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| Na Yuqing,Bao Shoukui. PROTECTIVE EFFECTS OF EIGHT KINDS OF SWERTIA POWDER ON ACUTE LIVER DAMAGE IN MICE[J]. Journal of Qinghai Medical College, 2011, 32(4): 253-255 |
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| Authors: | Na Yuqing Bao Shoukui |
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| Affiliation: | Na Yuqing,Bao Shoukui(1.Huzhu County People's hospital,Qinghai Province,2.Qinghai University Medical College) |
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| Abstract: | Objective To investigate the protective effects and mechanism of eight kinds of swertia powder on the acute liver damage caused by carbon tetrachloride(CCl4) in mice.Methods 40 healthy kun Ming mice were randomly divided into four groups.The experimental group was feed with eight kinds of swertia powder,450mg/kg/d,for 7 days.The second group was feed with Biphenyl Double Ester,11.3mg/kg/d for 7days.The blank control group and model group were feed with same amounts of distilled water.Three groups except bla... |
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| Keywords: | Mice Acute liver damage Eight kinds of swertia powder TNF -α IL - 10 |
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