| 内皮素-1及其受体在宫颈癌中的表达及意义 |
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| 引用本文： | 刘寿,简生燕,王兆芬,张发斌,李斌,杜文琪. 内皮素-1及其受体在宫颈癌中的表达及意义[J]. 青海医学院学报, 2011, 32(4): 226-230 |
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| 作者姓名： | 刘寿 简生燕 王兆芬 张发斌 李斌 杜文琪 |
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| 作者单位： | 1. 青海大学医学院
2. 青海省人民医院 |
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| 摘 要： | 目的探讨内皮素-1及其受体表达水平与宫颈癌的意义，以及其对宫颈癌发生过程的调控作用。方法收集临床标本89例，分为病例组（52例，宫颈癌组织）和正常对照组（37例，慢性宫颈炎组织）。采用半定量PCR和Westernblot法检测组织中ET-1、ETA、ETB的mRNA和蛋白的表达含量，并对检测数据行统计分析。结果宫颈癌病例组ET-1、ETA在mRNA表达水平上与正常对照组比较有明显增高趋势，差异具有显著性（P〈0．01），而ET—B在两组中的表达无显著性差异。宫颈癌病例组ET-1、ETA在蛋白水平上与对照组比较也有明显增高趋势（P〈0．01），而ET—B在两组中的表达无显著性差异。结论宫颈癌患者体内ET-1的过量表达与宫颈癌的发生、发展密切相关。ET-1在宫颈癌组织中发挥的生物学效应以ETA受体介导为主。
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| 关 键 词： | 宫颈癌 内皮素-1 内皮素受体 |
SIGNIFICANCE OF ENDOTHELIN-1 AND ENDOTHELIN RECEPTORS IN CERVICAL CARCINOMA |
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| Liu Shou,Jian Shengyan,Wang Zhaofen,Zhang Fabin,Li Bin,Du Wenqi. SIGNIFICANCE OF ENDOTHELIN-1 AND ENDOTHELIN RECEPTORS IN CERVICAL CARCINOMA[J]. Journal of Qinghai Medical College, 2011, 32(4): 226-230 |
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| Authors: | Liu Shou Jian Shengyan Wang Zhaofen Zhang Fabin Li Bin Du Wenqi |
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| Affiliation: | Liu Shou1,Jian Shengyan2,Wang Zhaofen1,Zhang Fabin1,Li Bin1,Du Wenqi1(1.Qinghai University Medicine College,2.Qinghai Province People's Hospital) |
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| Abstract: | Objective To explore the effect of endothelin-1 and its receptor on the process of regulation during suffering from cervical cancer.Methods A total of 89 clinical samples,were divided into the control group and the case group.The case group included 52 patients with cervical cancer;the control group included 37 cases of chronic cervicitis.Semi quantitative RT-PCR and Western blot were used to detect in the expression levels of ET-1,ETA,ETB mRNA and protein.Data were treated with statistics and analyzed by S... |
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| Keywords: | Cervical cancer Endothelin-1 Endothelin Receptor |
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