The induction of oral ethanol self-administration by contingent ethanol delivery |
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| Authors: | K A Grant H H Samson |
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| Affiliation: | 1. Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan;2. Department of Biosciences, COMSATS University (CU), Islamabad, Pakistan;3. Department of Chemistry, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan;4. Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS), International Islamic University (IIU), Islamabad, Pakistan;1. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Food Science and Technology, Ferdowsi University of Mashhad, Mashhad, Iran;4. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany;2. Department of Gastroenterology and Hepatology, Medical Center Bad Hersfeld, Seilerweg 29, 36251 Bad Hersfeld, Germany |
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| Abstract: | The necessity of delivering a highly reinforcing stimulus (20% sucrose) contingent upon ethanol consumption in order to induce ethanol self-administration in free-feeding rats was investigated. Rats water deprived for 12-16 h were placed in an environment in which ethanol drinking resulted in the presentation of ethanol. This procedure was successful in inducing and maintaining ethanol self-administration over concentrations of 5-20% (v/v). Compared to a group of rats initially reinforced for drinking ethanol with sucrose presentation, contingent ethanol delivery resulted in greater ethanol self-administration behavior. When 20% ethanol was available the group trained with ethanol had average intake of 0.91 g/kg, whereas the group trained with sucrose had a mean intake of 0.69 g/kg in a 30-min session. The results suggest that ethanol's reinforcing properties are sufficient to establish ethanol self-administration within the context of the inducing environment. |
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