Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma |
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Authors: | Huang Yu-Chuen Chen Marcelo Shyr Yi-Ming Su Cheng-Hsi Chen Chi-Kuan Li Anna Fen-Yau Ho Donald Ming-Tak Chen Yi-Ming Arthur |
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Affiliation: | AIDS Prevention and Research Center,;Division of Preventive Medicine, Institute of Public Health, School of Medicine,;Department of Microbiology, School of Medicine, National Yang-Ming University,;Department of Medical Research,;Department of Pathology, Taipei Mackay Memorial Hospital,;Mackay Medicine, Nursing and Management College,;Department of Surgery,;Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, and;Department of Urology, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan |
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Abstract: | Background and Aim: Glycine N -methyltransferase (GNMT) is a susceptibility gene for human hepatocellular carcinoma (HCC). We previously reported that GNMT expression is diminished in HCC. Here we report our examination of GNMT expression patterns in cholangiocarcinoma and the relationship between its expression and prognosis. Methods: We analyzed GNMT expression in tumor tissues from 33 cholangiocarcinoma patients (19 male) using immunohistochemistry (IHC) procedures with a GNMT monoclonal antibody (mAb 4–17). GNMT expression intensity and percentages were scored on a scale of 0 to 6. The association between GNMT expression and survival was analyzed using the Kaplan–Meier method, and prognostic factors were evaluated with a multivariate Cox proportional hazards regression model. Results: High GNMT expression was found in epithelial cells of normal bile ducts. Six of 33 (18.2%) cholangiocarcinoma tissues had no GNMT expression. A statistically significant difference was noted in GNMT expression between male and female patients (68.4% vs 100%, P < 0.05). Compared to patients with GNMT expression scores > 3, the death hazard ratio for patients with GNMT scores ≤ 3 was 3.68 (95% confidence interval = 1.17–11.59, P < 0.05). Conclusions: GNMT expression is a favorable prognosis predictor for cholangiocarcinoma. |
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Keywords: | cholangiocarcinoma glycine N-methyltransferase hepatocellular carcinoma immunohistochemistry |
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