血清铁蛋白联合前列腺特异性抗原检测对前列腺癌的诊断价值

目的探讨血清铁蛋白(Ferr)、总前列腺特异性抗原(tPSA)、游离前列腺特异性抗原(f PSA)、fPSA/tPSA联合检测对前列腺癌(PCa)的诊断价值。方法选择90例PCa患者、84例前列腺良性病变患者和50例健康男性体检者分别作为PCa组、良性组和对照组,检测3组研究对象的血清Ferr、tPSA、fPSA水平并计算fPSA/tPSA,分析Ferr、tPSA、fPSA、fPSA/tPSA联合检测对PCa的诊断价值。结果PCa组患者的血清Ferr、tPSA、fPSA水平均高于良性组和对照组,fPSA/tPSA低于良性组和对照组,差异均有统计学意义(P﹤0.05)。良性组患者的血清Ferr、tPSA、fPSA水平均高于对照组,fPSA/tPSA低于对照组,差异均有统计学意义(P﹤0.05)。PCa患者的血清Ferr与tPSA、fPSA均呈正相关,tPSA与f PSA呈正相关,tPSA与fPSA/tPSA呈负相关(P﹤0.05)。血清Ferr、tPSA、fPSA、fPSA/tPSA联合检测诊断PCa的灵敏度、特异度、曲线下面积均高于四个指标的三联、两联、单独检测。结论PCa患者的血清Ferr、t PSA、fPSA水平均高于前列腺良性病变患者,fPSA/tPSA低于前列腺良性病变患者。血清Ferr、tPSA、f PSA、f PSA/tPSA联合检测对PCa具有较高的诊断价值,值得在临床中推广应用。

Diagnostic value of combined detection of serum ferritin and prostate specific antigen in prostate cancer

Objective To investigate the diagnostic value of combined detection of serum ferritin(Ferr),total prostate specific antigen(tPSA),free prostate specific antigen(fPSA)and fPSA/tPSA for prostate cancer(PCa).Method The levels of serum Ferr,tPSA,fPSA and fPSA/tPSA in 90 PCa patients(PCa group),84 patients with benign prostate lesions(benign lesions group)and in 50 healthy subjects(control group)were detected and calculated,to determine the diagnostic value of combined detection of Ferr,tPSA,fPSA and fPSA/tPSA for PCa.Result The serum Ferr,tPSA and fPSA in PCa group were higher than those in benign lesions group and control group,while fPSA/tPSA was lower than that in benign lesions group and control group,the differences were of statistical significance(P<0.05).The serum Ferr,tPSA,and fPSA in benign lesions group were significantly higher compared to control group,with lower fPSA/tPSA versus control group(P<0.05).In PCa patients,the serum Ferr was positively correlated with tPSA and fPSA,besides,consistent positive correlation was observed between tPSA and fPSA,while tPSA was negatively correlated with fPSA/tPSA(P<0.05).The sensitivity,specificity and area under the curve(AUC)of combined detection of serum Ferr,tPSA,fPSA and fPSA/tPSA in the diagnosis of PCa were higher than those four measures utilized alone or in any form of combination of three or two.Conclusion Compared with patients with benign prostate lesions,the serum Ferr,tPSA,fPSA are significantly higher,and fPSA/tPSA is lower in PCa patients.The combined detection of the four measures is of relatively higher diagnostic value for PCa.