Adaptive optics optical coherence tomography with dynamic retinal tracking |
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| Authors: | Omer P Kocaoglu R Daniel Ferguson Ravi S Jonnal Zhuolin Liu Qiang Wang Daniel X Hammer Donald T Miller |
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| Institution: | 1.School of Optometry, Indiana University, Bloomington, IN 47405, USA;2.Physical Sciences, Inc, Andover, MA 01810, USA;3.Currently with the Department of Ophthalmology & Vision Science, University of California, Davis, CA 95616, USA;4.Currently with the Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA |
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| Abstract: | Adaptive optics optical coherence tomography (AO-OCT) is a highly sensitive and noninvasive method for three dimensional imaging of the microscopic retina. Like all in vivo retinal imaging techniques, however, it suffers the effects of involuntary eye movements that occur even under normal fixation. In this study we investigated dynamic retinal tracking to measure and correct eye motion at KHz rates for AO-OCT imaging. A customized retina tracking module was integrated into the sample arm of the 2nd-generation Indiana AO-OCT system and images were acquired on three subjects. Analyses were developed based on temporal amplitude and spatial power spectra in conjunction with strip-wise registration to independently measure AO-OCT tracking performance. After optimization of the tracker parameters, the system was found to correct eye movements up to 100 Hz and reduce residual motion to 10 µm root mean square. Between session precision was 33 µm. Performance was limited by tracker-generated noise at high temporal frequencies.OCIS codes: (110.1080) Active or adaptive optics, (170.4500) Optical coherence tomography, (120.3890) Medical optics instrumentation, (170.0110) Imaging systems, (170.4470) Ophthalmology, (330.5310) Vision - photoreceptors |
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