急性脑血管病的代谢紊乱特点及相关因素的多元回归分析

目的探讨急性脑血管病时代谢紊乱的特点和进一步寻找其相关因素,为脑血管病的防治提供依据.方法在对202名正常人及623例急性脑血管病(381例脑梗死、242例脑出血)患者住院的基线资料进行回顾性分析的基础上,进行多元回归分析.结果 (1)急性脑血管病患者的年龄、体重指数(BMI)、血压、血糖、低密度脂蛋白(LDL)值均显著高于对照组(P<0.05).(2)脑梗死、脑出血患者中,伴高血压者分别为91.7%、92.1%;伴高血糖者分别为49.3%、36.8%;伴高甘油三酯(TG)/低高密度脂蛋白(HDL)分别为29.7%、36.0%.(3)脑梗死、脑出血患者中,合并代谢综合征者分别占12.1%、19.4%;合并两种代谢紊乱者分别占44.3%、39.7%;合并1种代谢紊乱者分别占39.9%、38.6%;无代谢紊乱者仅分别占3.7%、2.3%.同时,除合并代谢紊乱者血压均显著高于对照组及无代谢紊乱者外,合并两种以上代谢紊乱患者中BMI、血糖、TG、LDL均高于对照组及无代谢紊乱者(P<0.05).(4)相关分析显示,代谢紊乱因素中,年龄、血糖、血压、BMI及LDL与急性脑血管病明显相关.结论急性脑血管病患者多伴有代谢紊乱,提示有效控制代谢紊乱,有利于急性脑血管病的防治.

Characters of metabolic disorder in acute cerebral vascular disease and multivariate regress analysis of its related factors

Objective To investigate characters of metabolic disorder in acute cerebral vascular disease(ACVD),to explore its related factors,and to provide clinical basis for intervention of ACVD.Methods Based on analysis of the data of 202 healthy individuals and 623 cases of ACVD(381 patients with cerebral infarction and 242 patients with cerebral haomorrhage),multivariate regress analysis of its related factors were done.Result (1)Age,BMI,blood pressure,plasma glucose in patients with ACVD were significantly higher than those in the control group.(2)Of the patients with cerebral infarction,91.7% had hypertention,49.3% had hyperglycemia and 29.7% had H TG/L HDL.Of the patients with cerebral haomorrhage,92.1% had hypertention,36.8% had hyperglycemia and 36.0% had H TG/L HDL.(3)Of the patients with cerebral infarction,12.1% had metabolic syndrome(MS),44.3% had two kinds of metabolic disorder,39.9% had one kind and only 3.7% had none.Of the patients with cerebral haomorrhage,19.4% had MS,39.7% had two kinds of metabolic disorder,38.6% had one kind and only 2.3% had none.Moreover,in those with ACVD,besides the blood pressure was significantly higher than those in control group and no metabolic disorder group,the BMI,plasma glucose,TG and LDL in those in two kinds of metabolic disorder and MS were higher than those in control group and none of metabolic disease group.(4)The age,BMI,blood pressure,plasma glucose and LDL had obvious correlation with ACVD.Conclusion ACVD is often combined with various kinds of metabolic disorders,suggesting that an effective control of metabolic disorders is benefit to intervention of ACVD.