| Toll样受体与固有免疫的进化 |
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| 引用本文： | Liu Y,Zhu LP,He W. Toll样受体与固有免疫的进化[J]. 中国医学科学院学报, 2002, 24(4): 433-436 |
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| 作者姓名： | Liu Y Zhu LP He W |
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| 作者单位： | 1. 中国协和医科大学临床医学98级,北京,100730
2. Department of Immunology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005 |
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| 摘 要： | 固有免疫是在进化中形成的免疫机制,在对抗微生物的入侵方面,固有免疫的策略是通过模式识别受体(PRR)识别微生物的病原相关分子模式(PAMP)。Toll样受体是近年来在多种生物体内发现的一类介导固有免疫的细胞膜受体家族,它通过活化一系列与免疫相关的基因表达而发挥作用,在进化中表现高度的保守性,但其功能却随着动物进化中免疫机能的复杂化而多样化。对Toll样受体研究的深入可以加深我们对固有免疫的发生与进化的认识。
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| 关 键 词： | 病原相关分子模式 模式识别受体 Toll样受体 固有免疫 |
| 修稿时间： | 2002-05-14 |
Toll-like receptor and innate immunity in phylogenesis |
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| Liu Ye,Zhu Li-ping,He Wei. Toll-like receptor and innate immunity in phylogenesis[J]. Acta Academiae Medicinae Sinicae, 2002, 24(4): 433-436 |
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| Authors: | Liu Ye Zhu Li-ping He Wei |
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| Affiliation: | Department of Clinical Medicine, PUMC, Beijing 100730, China. |
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| Abstract: | In protection against microbes,an organism recognizes the pathogen associated molecular pattern(PAMP)on microbes by pattern recognition receptor(PRR).Toll-like receptor is called innate immunity.A family of cell membrane receptor was found in recent years that can mediate innate immune responses through the activation of a series of immune-related genes.In phylogenesis,it is highly conservative.However,its functions are getting more diversified with the complication of the immune functions of organisms. |
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| Keywords: | pathogen associated molecular pattern pattern recognition receptor Toll-like receptor innate immunity |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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