| 观光木根皮的ICR鼠体内抑瘤作用初步研究 |
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| 引用本文： | 宋晓凯,吴立军,屠鹏飞,蔡阳,李寅增. 观光木根皮的ICR鼠体内抑瘤作用初步研究[J]. 沈阳药科大学学报, 2001, 18(4): 283-285 |
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| 作者姓名： | 宋晓凯 吴立军 屠鹏飞 蔡阳 李寅增 |
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| 作者单位： | 1. 沈阳药科大学中药系
2. 北京大学药学院 |
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| 基金项目： | 国家自然科学基金资助项目(29732040) |
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| 摘 要： | 对中国特有植物观光木 (TsoongiodendronodorumChun)根皮 95 %乙醇浸膏的乙酸乙酯萃取部分及首次从观光木属植物中分离得到的木香烯内酯 (costunolide)进行了ICR鼠体内S 180荷瘤的抑瘤作用研究 ,结果表明 ,该部分的 3 0 0 g/kg剂量组及木香烯内酯 (12 0 0mg/kg)剂量组经连续10d灌胃给药 ,对ICR鼠体内S 180荷瘤确有明显的抑瘤作用。
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| 关 键 词： | 观光木根皮 体内抑瘤活性 木香烯内酯 |
| 文章编号： | 1006-2858(2001)04-0283-03 |
| 修稿时间： | 2000-11-22 |
Studies on the inhibitory effect of the root barks of Tsoongiodendron odorum Chun on the ICR mouse sarcoma in vivo |
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| SONG Xiao kai,WU Li jun,TU Peng fei,CAI Yang,LI Yin zeng. Studies on the inhibitory effect of the root barks of Tsoongiodendron odorum Chun on the ICR mouse sarcoma in vivo[J]. Journal of Shenyang Pharmaceutical University, 2001, 18(4): 283-285 |
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| Authors: | SONG Xiao kai WU Li jun TU Peng fei CAI Yang LI Yin zeng |
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| Abstract: | The studies of the inhibitory effect on the ICR mouse sarcoma were made for the EtOAc section of 95% ethanol extract of the root barks of T. odorum Chun and costunolide, which was isolated from the EtOAc section. The result indicated that the EtOAc section and costunolide ( 12 00 mg/kg ) had evident inhibitory effect on ICR mouse S 180 sarcoma. The growth of the ICR mouse sarcoma was inhibited evidently when the oral dosage of the EtOAc section was 3 00 g/kg . |
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| Keywords: | root barks of T.odorum Chun activity of inhibiting sarcoma costunolide |
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